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49ers vs Titans Thursday Night Football Picks and Predictions

Expert NFL picks, predictions and preview for this San Francisco 49ers vs. Tennessee Titans Thursday night game kicking off at 8:20pm et.

49ers vs Titans Game Preview

This San Francisco 49ers vs Tennessee Titans Thursday Night Football game is set to kickoff on December 23, 2021 at 8:20pm et at the Nashville Nissan Stadium.

The NFL Odds have the 49ers listed as a -3 favorite against the spread with the over/under at 44.5 total points.

62% of the public betting have their money behind San Francisco as the road favorite.

This will be the first time this season these two teams meet each other.

San Francisco 49ers Betting Preview

The 49ers come into this game red hot winning their last two games in a row making that 4 wins in their last 5 games. They are now sitting 8-6 overall and this game has huge playoff implications for them.

In San Fran’s Week 15 win against the Falcons, 31-13, they were without running back Elijah Mitchell, but Jeffrey Wilson stepped it up big time putting up 21 carries for 110 yards.

Unfortunately for the Niners, Elijah Mitchell has also been ruled out for this Thursday Night game. It’s going to be extremely tough for Wilson to put up those type of numbers again against this Titans defense who’s currently have the second best defense against the run in the league.

The 49ers on the road this season have the tenth best offense in the NFL that’s scoring an average of 25.7 points per game. Their road defense this season has been pretty decent since they are only giving up an average of 21 points per game.

San Francisco is 5-1 against the spread in their last 6 games, but 1-7-1 against the spread in their last 9 games against Tennessee. The total has gone over in 6 of the 49ers last 8 games against an opponent in the AFC South.

Tennessee Titans Betting Preview

The Tennessee Titans come into this game still at the top on the AFC South at 9-5, but didn’t look so hot against the Steelers on Sunday in the 19-13 road loss. They almost had double the time of possession as Pittsburgh, but 3 fumbles, 1 interception, and all the penalties really cost them.

Coach Mike Vrabel should have those mistakes under control a little better this week, but without their stud running back Derrick Henry on the field, it’s been tough for them to get into a balanced rhythm.

Wide receiver Julio Jones got banged up last game, but reports show him in the lineup for this one. Also, even more good news is that you could also see the return of wide receiver AJ Brown. The bad news for Tennessee is that their left tackle and left guard have been ruled out for this matchup.

The Titans are 1-4 against the spread in their last 5 games, but 4-1 against the spread in their last 5 games against an opponent in the NFC West.

The total has gone under in 4 of Tennessee’s last 6 games. This Titans when playing at home this season are scoring an average of 22 points per game, but their home defense is the eighth best in the league right now, that’s only giving up an average of 18.7 points per game.

Free NFL Picks:

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